DNA Repair & Cancer Research Laboratory
Publications
2023
168. Ujjayinee Ray, Vindya K Gopinatha, Shivangi Sharma, Laijau Goyary, Bibha Choudhary, Kempegowda Mantelingu, Kanchugarakoppal S Rangappa and Sathees C Raghavan
Identification and characterization of mercaptopyrimidine-based small molecules as inhibitors of nonhomologous DNA end joining.
(2023) FEBS J doi: 10.1111/febs.16615. PMID: 36048168.
2022
167. Sumedha Dahal, Humaira Siddiqua, Shivangi Sharma, Ravi K Babu, Diksha Rathore, Sheetal Sharma and Sathees C Raghavan
Unleashing a novel function of endonuclease G in mitochondrial genome instability.
(2022) Elife. 2022;11:e69916.
166. Anju Sharma, Arigesh Kaninathan, Sumedha Dahal, Susmita Kumari, Bibha Choudhary and Sathees C Raghavan
Exposure to Endosulfan can Cause Long Term Effects on General Biology, Including the Reproductive System of Mice.
(2022) Front. Genet. Nov 24;13:1047746. doi: 10.3389/fgene.2022.1047746. eCollection 2022.PMID: 36506329
165. Amita M Paranjape, Sagar S Desai, Mayilaadumveettil Nishana, Urbi Roy, Namrata M Nilavar, Amrita Mondal, Rupa Kumari, Gudapureddy Radha, Vijeth Kumar Katapadi, Bibha Choudhary and Sathees C Raghavan
Nonamer dependent RAG cleavage at CpGs can explain mechanism of chromosomal translocations associated to lymphoid cancers.
(2022) PLoS Genet. 18(10):e1010421.
164. Dipayan Ghosh, Namrata Madan Nilavar and Sathees C Raghavan
A novel KU70-mutant human leukemic cell line generated using CRISPR-Cas9 shows increased sensitivity to DSB inducing agents and reduced NHEJ activity.
(2022) Biochim Biophys Acta Gen Subj. 1866(12):130246.
163. Dipayan Ghosh, Susmita Kumari, Sathees C Raghavan
Depletion of RNASEH2 activity leads to accumulation of DNA double-strand breaks and reduced cellular survivability in T cell leukemia.
(2022) J Mol Biol. 2022 434(12):167617.
162. Sumedha Dahal, Humaira Siddiqua, Vijeth K Katapadi, Divyaanka Iyer, Sathees C Raghavan
Characterization of G4 DNA formation in mitochondrial DNA and their potential role in mitochondrial genome instability.
(2022) FEBS Journal, 289(1):163-82.
161. Sagar S Desai, S Whadgar, Sathees C Raghavan, Bibha Choudhary
MiRAGDB: a knowledgebase of RAG regulators.
(2022) Frontiers in Immunology, 13:863110.
2021
160. Ujjayinee Ray, Shivangi Sharma, Indu Kapoor, Susmita Kumari, Vidya Gopalakrishnan, Supriya V Vartak, Nitu Kumari, Umesh Varshney, Sathees C Raghavan
G4 DNA present at human telomeric DNA contributes towards reduced sensitivity to γ-radiation induced oxidative damage, but not bulky adduct formation.
(2021) International Journal of Radiation Biology, 14:1-26.
159. Rupa Kumari*, Urbi Roy*, Sagar S Desai, Namrata M Nilavar, Van Nieuwenhuijze, Amita Paranjape, Radha Gudapureddy, P Bawa, Mrinal Srivastava, Mridula Nambiar, KN Balaji, Adrian Liston, Bibha Choudhary, Sathees C Raghavan (*equals first authors).
MicroRNA miR-29c regulates RAG1 expression and modulates V(D)J recombination during B cell development.
(2021) Cell Reports, 36 (2):109390.
158. Ujjayinee Ray, Sathees C Raghavan
Understanding the DNA double-strand break repair and its therapeutic implications.
(2021) DNA Repair, 106:103177.
157. Vidya Gopalakrishnan, Shivangi Sharma, Ujjayinee Ray, Meghana Manjunath, Divya Lakshmanan, Supriya S Vartak, Vindya K Gopinatha, Mrinal Srivastava, Mantelingu Kempegowda, Bibha Choudhary, Sathees C Raghavan
SCR7, an inhibitor of NHEJ can sensitize tumor cells to ionization radiation.
(2021) Molecular Carcinogenesis, 60 (9):627-43.
156. Shivangi Sharma, Varsha KK, Ujjayinee Ray, Humaira Siddiqua, Anjana Elizabeth Jose, S Muninarasimaiah, Sathees C Raghavan, Bibha Choudhary
Acute toxicity analysis of an inhibitor of BCL2, Disarib, in rats.
(2021) Scientific Reports, 11 (1):9982.
155. Dipayan Ghosh, Sathees C Raghavan
20 years of DNA Polymerase μ, the polymerase that still surprises.
(2021) FEBS Journal, 288(24):7230-42.
154. Urbi Roy, Sathees C Raghavan
Deleterious point mutations in T-cell acute lymphoblastic leukemia: Mechanistic insights into leukemogenesis.
(2021) International Journal of Cancer, 149(6):1210-1220.
153. Dipayan Ghosh, Sathees C Raghavan
Nonhomologous end joining: new accessory factors fine tune the machinery. (2021) Trends in Genetics, 37(6):582-599.
152. Sumedha Dahal, Sathees C Raghavan
Mitochondrial genome stability in human: understanding the role of DNA repair pathways.
(2021) Biochemical Journal, 478(6):1179-1197.
151. Namrata M Nilavar, Sathees C Raghavan
HIV integrase inhibitors that inhibit strand transfer interact with RAG1 and hamper its activities.
(2021) International Immunopharmacology, 95:107515.
150. ER Maddi, Sathees C Raghavan, Natesh R.
Hypomorphic mutations in human DNA ligase IV lead to compromised DNA binding efficiency, hydrophobicity and thermal stability.
(2021) Protein Engineering Design and Selection, 34:gzab001.doi: 10.1093/protein/gzab001.
149. Nitu Kumari , Sathees C Raghavan
G-quadruplex DNA structures and their relevance in radioprotection.
(2021) Biochimica et Biophysica Acta, General Subjects, 1865(5):129857.
148. Meghana Manjunath, Bibha Choudhary, Sathees C Raghavan
SCR7, a potent cancer therapeutic agent and a biochemical inhibitor of nonhomologous DNA end-joining.
(2021) Cancer Reports, 4(3):e1341.
2020
147. Saniya M Javadekar, Namrata M Nilavar, Amita Paranjape, Kohal Das, Sathees C Raghavan
Characterization of G-quadruplex antibody reveals differential specificity for G4 DNA forms.
(2020) DNA Research, 27(5):dsaa024.
146. Ujjayinee Ray, Sathees C Raghavan
Modulation of DNA double-strand break repair as a strategy to improve precise genome editing
(2020) Oncogene 39(41):6393-6405.
145. Namrata M Nilavar, Mayilaadumveettil Nishana, Amita Paranjape, R Mahadeva, Rupa Kumari, Bibha Choudhary, Sathees C Raghavan
ZnC2 module of RAG1 Contributes towards Structure-specific Nuclease activity of RAGs.
(2020) Biochem J. 477(18):3567-3582.
144. Ujjayinee Ray, Franklin John, Sayeesh Pooppadi, Jinu George, Shivangi Sharma, Sathees C Raghavan
Synthesis of novel aromatic thiourea derivatives and investigations on their cytotoxic potential efficacy
(2020) Journal of Heterocyclic Chemistry 58(1).
143. Ujjayinee Ray, Sathees C Raghavan
Inhibitors of DNA double-strand break repair at the crossroads of cancer therapy and genome editing
(2020) Biochem Pharmacol. 2020 Dec; 182:114195.
142. Shivangi Sharma, Kontham Kulangara Varsha, Susmita Kumari, Vidya Gopalakrishnan, Anjana Elizabeth Jose, Bibha Choudhary, Kempegowda Mantelingu, Sathees C Raghavan
Acute toxicity analysis of Disarib, an inhibitor of BCL2
(2020) Scientific Reports 10(1):15188.
141. Ujjayinee Ray, Anjana Elizabeth Jose, Rohini Suresh, Uthara Kaloor, Hassan A. Swarup, Mridula Nambiar and Sathees C Raghavan
Water-soluble SCR7 can abrogate DNA End joining and induce cancer cell death
(2020) Clinical Oncology Research, Volume 3(7): 2-7 doi:10.31487/j.COR.2020.07.09.
140. Nilavar NM, Paranjape AM, Sathees C Raghavan
Biochemical activity of RAGs is impeded by Dolutegravir, an HIV integrase inhibitor (2020), Cell Death Discov. 10.1038/s41420-020-0281-4
139. Ujjayinee Ray, Vartak SV, Sathees C Raghavan
NHEJ inhibitor SCR7 and its different forms: Promising CRISPR tools for genome engineering
(2020) Gene 763:144997. doi: 10.1016/j.gene.2020.144997. Epub 2020 Aug 9.
138. Ujjayinee Ray, Raul SK, Gopinatha VK, Ghosh D, Rangappa KS, Mantelingu K, Sathees C Raghavan
Identification and characterization of novel SCR7-based small-molecule inhibitor of DNA end-joining, SCR130 and its relevance in cancer therapeutics
(2020) Molecular Carcinogenesis 59:618-628.
137. Vindya K. Gopinatha, Ujjayinee Ray, Kempegowda Mantelingu, Sathees C. Raghavan and Kanchugarakoppal. S. Rangappa
Synthesis and Biological Evaluation of Theophylline Methyl 1,3,4- Oxadiazole as Anticancer Agents
(2020) Russian Journal of Bioorganic Chemistry, 46,837–844.
2019
136. Nitu Kumari, Supriya V Vartak, Sumedha Dahal, Susmita Kumari, Sagar S Desai, Vidya Gopalakrishnan, Bibha Choudhary, Sathees C Raghavan G-quadruplex Structures Contribute to Differential Radiosensitivity of the Human Genome
(2019) iScience 21:288-307.
135. Vindya K. Gopinatha, Hassan A. Swarupa, Sathees C. Raghavan, Kempegowda Mantelingu and Kanchugarakoppal S. Rangappa
Discovery of Novel Approach for Regioselective Synthesis of Thioxotriaza-Spiro Derivatives via Oxalic Acid
(2019) Synlett, 30, 2004-2009.
134. Monica Pandey, Vidya Gopalakrishnan, Hassan A Swarup, Sujeet Kumar, Radha Gudapureddy, Anjana Elizabeth Jose, Supriya V Vartak, Robin Sebastian, Mrinal Srivastava, Bibha Choudhary, Mantelingu Kempegowda, Subhas S Karki, Sathees C Raghavan
Water-soluble version of SCR7-pyrazine inhibits DNA repair and abrogates tumor cell proliferation
(2019) Journal of Radiation and Cancer Research. 10:27.
133. Vidya Gopalakrishnan, Dahal S, Radha G, Sharma S, Sathees C Raghavan, Choudhary B. Characterization of DNA double-strand break repair pathways in diffuse large B cell lymphoma
(2019) Molecular Carcinogenesis 58:219-233.
2018
132. Supriya V Vartak, Swarup HA, Gopalakrishnan V, Gopinatha VK, Ropars V, Nambiar M, John F, Kothanahally SKS, Kumari R, Kumari N, Ray U, Radha G, Dinesh D, Pandey M, Ananda H, Karki SS, Srivastava M, Charbonnier JB, Choudhary B, Mantelingu K, Sathees C Raghavan
Autocyclized and oxidized forms of SCR7 induce cancer cell death by inhibiting nonhomologous DNA end joining in a Ligase IV dependent manner
(2018) FEBS Journal 285(21):3959-3976.
131. Vidya Gopalakrishnan, G Radha, Sathees C Raghavan, Bibha Choudhary
Inhibitor of nonhomologous end joining can inhibit proliferation of diffuse large B-Cell lymphoma cells and potentiate the effect of ionization radiation
(2018) Journal of Radiation and Cancer Research 9, 93-104.
130. Greeshma Devassy, Ranjith Ramachandran, Kottarapat Jeena, Vijayabhaskar R Junnuthula, Vindya K Gopinatha, Cheripelil A Manju, Maneesh Manohar, Shantikumar V Nair, Sathees C Raghavan, Manzoor Koyakutty
Simultaneous release of two drugs from polymer nano-implant inhibits recurrence in glioblastoma spheroids
(2018) Precision Nanomedicine 2, 218-229.
129. Vivek Tripathi, Himanshi Agarwal, Swati Priya, Harish Batra, Priyanka Modi, Monica Pandey, Dhurjhoti Saha, Sathees C. Raghavan and Sagar Sengupta
MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways
(2018) Nature Communications 9 (1):10.
128. Saniya M Javadekar, Rakhee Yadav and Sathees C. Raghavan
DNA structural basis for fragility at peak III of BCL2 major breakpoint region associated with t(14;18) translocation
(2018) Biochimica et Biophysica Acta (General Subjects) 1862 (3): 649-659.
127. Sumedha Dahal, Shubam Dubey and Sathees C. Raghavan
Homologous Recombination Mediated Repair of DNA Double-strand Breaks Operates in Mammalian Mitochondria
(2018) Cellular and Molecular Life Sciences, 75(9):1641-1655.
126. Chaithanya Somu, Mahesh Hegde, Kothanahally S Sharath Kumar, Ananda Hanumappa, Mrinal Srivastava, Kachigere B Harsha, Chakrabhavi D Mohan, Kavya Ananthaswamy, Sathees C. Raghavan and Kanchugarakoppal S Rangappa
Synthesis and Biological Evaluation of Novel Thiazol-2yl-amine Derivatives as Potential Anticancer Agents
(2018) Letters in Organic Chemistry 15: 270-281.
125. Sneha Mishra, Ankit Kumar Tamta, Mohsen Sarikhani, Perumal Arumugam Desingu, Shruti M Kizkekra, Anwit Shriniwas Pandit, Shweta Kumar, Danish Khan, Sathees C. Raghavan and Nagalingam R Sundaresan
Subcutaneous Ehrlich Ascites Carcinoma mice model for studying cancer-induced cardiomyopathy
(2018) Scientific Report 8: 5599.
2017
124. Gudapureddy Radha and Sathees C. Raghavan
BCL2: A promising cancer therapeutic target
(2017) Biochim Biophys Acta (Reviews on Cancer) 1868(1):309-314.
123. Krishnaraj J, Kowshik J, Sebastian R, Sathees C Raghavan, Nagini S
Exposure to welding fumes activates DNA damage response and redox-sensitive transcription factor signalling in Sprague-Dawley rats
(2017) Toxicology Letters 274:8-19.
121. Mayilaadumveettil Nishana, Namrata M. Nilavar, Rupa Kumari, Monica Pandey and Sathees C. Raghavan
HIV Integrase Inhibitor Impairs RAG Functions and Inhibits V(D)J Recombination
(2017) Cell Death Dis. 8(6): e2852.
120. Mahesh Hegde, Vartak SV, Chandagirikoppal V. Kavitha, Ananda Hanumappa, Doddakunche S. Prasanna, Vidya Gopalakrishnan, Bibha Choudhary, Kanchugarakoppal S. Rangappa and Sathees C. Raghavan
A Benzothiozole Derivative (5g) Induces DNA Damage and Potent G2/M Arrest in Cancer Cells
(2017) Sci. Rep. 7(1):2533.
119. Supriya Vartak, Divyaanka Iyer, Santhoshkumar T.R., Sheetal Sharma, Archita Mishra, Gunaseelan Goldsmith, Mrinal Srivastava, Shikha Srivastava, Subhas S. Karki, Avadhesha Surolia, Bibha Choudhary and Sathees C. Raghavan
Novel BCL2 inhibitor, Disarib Induces Apoptosis by Disruption of BCL2-BAK Interaction
(2017) Biochemical Pharmacology, 131:16-28.
118. Shikha Srivastava, Sumedha Dahal, Sharanya Naidu, Deepika Anand, Vidya Gopalakrishnan, Rajendran Kooloth Valappil and Sathees C Raghavan
DNA Double-strand Break Repair in Penaeus monodon is Predominantly Dependent on Homologous Recombination
(2017) DNA Research. 24(2):117-128.
117. Robin Sebastian and Sathees C. Raghavan
Molecular Mechanism of Endosulfan action in Mammals
(2017) J. Bioscience. 42(1):149-153.
116. Monica Pandey and Sathees C. Raghavan
DNA double-strand break repair in mammals
(2017) J Radiat Cancer Res. 8:93-7.
115. Ghoshal N, Sharma S, Banerjee A, Kurkalang S, Sathees C. Raghavan, Chatterjee A
Influence of reduced glutathione on end-joining of DNA double-strand breaks:
Cytogenetical and molecular approach
(2017) Mutat Res. 795:1-9.
114. Hanumappa Ananda, Kothanahally S. SharathKumar, Kondappa M. Purushotham, Mayilaadumveettil Nishana, Mahesh Hegde, Mrinal Srivastava, Raghava Byregowda, Suguna Rao, Sathees C. Raghavan* and Kanchugarakoppal S. Rangappa*
Novel small molecule, pyrazole derivatives induces apoptosis and acts as an antagonist in DMBA induced mammary carcinoma cells
(2017) Mol. Cell. Biochem. 426:149-160.
113. Monica Pandey, Sujeet Kumar, Goldsmith G, Mrinal Srivastava, Santhini Elango, Mohammed Shameem, Dibyendu Bannerjee, Bibha Choudhary, Subhas S. Karki and Sathees C. Raghavan
Identification and Characterization of Novel Ligase I Inhibitors
(2017) Molecular Carcinogenesis 56:550-566.
2016
112. Elizabeth Thomas, Vidya Gopalakrishnan, Mahesh Hegde, Sujeet Kumar, Subhas S. Karki, Bibha Choudhary and Sathees C. Raghavan
A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells
(2016) Sci. Rep. 6:34653.
111. Supriya V. Vartak, Mahesh Hegde, Divyaanka Iyer, Snehal Gaikwad, Mrinal Srivastava, Vidya Gopalakrishnan, Subhas S. Karki, Bibha Choudhary, Pritha Ray and Sathees C. Raghavan
A Novel Inhibitor of BCL2 Induces Tumor Regression By Activating Intrinisic Pathway of Apoptosis
(2016) Biochemical Pharmacology. 122:10-22.
110. Robin Sebastian and Sathees C. Raghavan
Induction of DNA Damage and Erroneous Repair can Explain Genomic Instability Caused by Endosulfan
(2016) Carcinogenesis. 37:929-40.
109. Divyaanka Iyer*, Supriya V. Vartak*, Archita Mishra, G. Goldsmith, Sujeet Kumar, Mrinal Srivastava, Mahesh Hegde, Mark Glenn, Mahesh Velusamy, Bibha Choudhary, Nagesh Kalakonda, Subhas S. Karki , Avadhesha Surolia and Sathees C. Raghavan Identification of a Novel BCL2 Specific Inhibitor that Binds Predominantly to its BH1 Domain
(2016) FEBS J. 283:3408-37.
108. Kohal Das, Mrinal Srivastava and Sathees C. Raghavan
GNG Motif can Replace a Stretch of Guanines During G-Quadruplex Formation and is Context Dependent
(2016) Plos One.11:e0158794.
107. Mahesh Hegde*, Kempegowda Mantelingu*, Monica Pandey, Chottanahalli S. Pavankumar, Kanchugarakoppal S. Rangappa and Sathees C. Raghavan
A Novel Poly (ADP-ribose) Polymerase Inhibitor Shows Synergistic Effect with HDAC inhibitor, SAHA and Induces Apoptosis in Leukemic cells in a PARP Dependent Manner
(2016) Targeted Oncology.11:655-665.
106. Shikha Srivastava, Somasagara R. Ranganatha, Mayilaadumveettil Nishana, Satish Kumar Tadi, Mrinal Srivastava, Bibha Choudhary and Sathees C. Raghavan
Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis.
(2016) Sci. Rep. 6: 24049.
105. Elizabeth Thomas, Vidya Gopalakrishnan, Bibha Choudhary and Sathees C. Raghavan Extract of Vernonia condensata, Inhibits Tumor Progression and Improves Survival of Tumor-allograft Bearing Mouse
(2016) Sci. Rep. 6: 23255.
104. Satish Kumar Tadi, Robin Sebastian, Sumedha Dahal, Ravi K Babu, Bibha Choudhary and Sathees C. Raghavan
Microhomology Mediated End Joining is the Principal Mediator of Double-strand Break Repair During Mitochondrial DNA Lesions
(2016) Mol Biol Cell. 27: 223-35.
103. Deepthi Raveendran and Sathees C. Raghavan
Biochemical characterization of nonamer binding domain of Rag1 reveals its thymine preference with respect to length and position
(2016) Sci Rep. 6:19091.
102. Mahesh Hegde, Kempegowda Mantelingua, Hassan A. Swarupa, Chottanahalli S. Pavankumara, Imteyaz Qamarb, Sathees C. Raghavan and Kanchugarakoppal S. Rangappa
Novel PARP Inhibitors Sensitize Human Leukemic Cells in an Endogenous PARP Activity Dependent Manner
(2016) RSC Advances 6:6308-6319.
101. Ananda Hanumappa, Kothanahally S Sharath Kumar, Mahesh Hegde, Kereyagalahally H Narasimhamurthy, Sathees C Raghavan, Kanchugarakoppal S Rangappa
In Vitro Topoisomerase II Inhibitory and Apoptotic Activities of Novel 3, 5 Disubstituted Thiophene-2-carboxylates
(2016) Org. Med. Chem. IJ 1 1-7.
100. Satheesh George, Delse P Sebastian, CV Kavitha, Sathees C Raghavan, Anu Augustine, Praveen Kusumanchi
In vitro antiproliferative effect of the root extracts from Decalepis hamiltonii, Hemidesmus indicus and Utleria salicifolia
(2016) Devagiri Journal of Science 2, 52-57.
99. Kishore K. Chiruvella, Nishana M, VidyaGopalakrishnan, Somasagara R. Ranganatha, Tadi Satish Kumar, Santhini Elango, Sathees C. Raghavan and Bibha Choudhary Plant-derived Tetranortriterpenoid, Methyl Angolensate Activates Apoptosis and Prevents Ehrlich Ascites Carcinoma Induced Tumorigenesis in Mice
(2016) Journal of Advances in Medicine and Medical Research 12:1-10.
2015
98. Robin Sebastian and Sathees C. Raghavan
Endosulfan Induces Male Infertility
(2015) Cell Death Disease 6:e2022.
97. Robin Sebastian and Sathees C. Raghavan
Exposure to Endosulfan can Result in Male Infertility Due to Testicular Atrophy and Reduced Sperm Count
(2015) Cell Death Discovery. 1:1-10.
96. Mahesh Hegde, Kothanahally S. Sharath Kumar, Elizabeth Thomas, Ananda Hanumappa, Sathees C. Raghavan and Kanchugarakoppal S. Rangappa
A novel benzimidazole derivative binds to DNA minor groove and induces apoptosis in leukemic cells
(2015) RSC Advances, 5, 93194-93208.
95. Supriya Vartak, Sathees C Raghavan
Inhibition of nonhomologous end joining to increase the specificity of CRISPR/Cas9 genome editing.
(2015) FEBS J. 282:4289-94.
94. Naveen Kumar SK, Thushara RM, Sundaram MS, Hemshekhar M, Paul M, Thirunavukkarasu C, Basappa, Nagaraju G, Sathees C Raghavan, Girish KS, Kemparaju K, Rangappa KS
Unconjugated Bilirubin exerts Pro-Apoptotic Effect on Platelets viap38-MAPK activation.
(2015) Scientific Report 5:15045.
93. Mohammed A, Chiruvella KK, Rao YK, Geethangili M, Sathees C Raghavan, Ghanta RG.
In vitro Production of Echioidinin, 7-O-Methywogonin from Callus Cultures of Andrographis lineata and Their Cytotoxicity on Cancer Cells.
(2015) PLoS One. 10:e0141154.
92. Kothanahally S. Sharath Kumar, Ananda Hanumappa, Maruthai Vetrivel, Mahesh Hegde, Yarabhally R. Girish, Thinnali R. Byregowda, Suguna rao, Sathees C. Raghavan, Kanchugarakoppal S. Rangappa
Antiproliferative and tumor inhibitory studies of 2,3 disubstituted 4-thiazolidinone derivatives
(2015) Bioorg. Med. Chem. Let. 25:3616-20.
91. Saniya M. Javadekar and Sathees C. Raghavan
Snaps and Mends: DNA breaks and Chromosomal Translocations
(2015) FEBS J.:282:2627-45.
90. Arpit Katiyar, Mahesh Hegde, Sujeet Kumar, Vidya Gopalakrishnan, Khyati D. Bhatelia, Kavya Ananthaswamy, Sureshbabu A. Ramareddy, Erik De Clercq, Bibha Choudhary, Dominique Schols, Sathees C. Raghavan and Subhas S. Karki
Synthesis and evaluation of the biological activity of N'-[2-oxo-1,2 dihydro-3H-indol-3-ylidene] benzohydrazides as potential anticancer agents
(2015) RSC Advances. 5:45492-45501.
89. Franklin John, Jinu George, Mrinal Srivastava, P. A. Hassan, V.K. Aswal, Subhas S. Karki, Sathees C. Raghavan
Pluronic Copolymer Encapsulated SCR7 as a potential anti cancer agent.
(2015) Faraday Discussions. 177: 155-61.
88. Rupa Kumari, Mridula Nambiar, Shaika Shanbagh and Sathees C. Raghavan
Detection of Non-B DNA Structure Using Primer Extension as a Tool
(2015) PLOS One. 10: e0119722.
87. Sheetal Sharma, Saniya M. Javadekar, Monica Pandey, MrinalSrivastava, RupaKumari and Sathees C. Raghavan
Homology and Enzymatic Requirements of Microhomology Dependent Alternative End Joining
(2015) Cell Death Diseases 6: e.1697.
86. Rohit Kumar HG, Asha KR, Sathees C. Raghavan, Advi Rao GM
DNA intercalative 4-butylaminopyrimido [4',5':4,5] thieno(2,3-b) quinoline induces cell cycle arrest and apoptosis in leukemia cells
(2015) Cancer Chemother Pharmacol. 75:1121-33.
85. Mrinal Srivastava and Sathees C. Raghavan
DNA repair inhibitors in Cancer therapeutics
(2015) Chemistry & Biology. 22: 17-29.
84. Rupa Kumari and Sathees C. Raghavan
Structure-specific Nuclease Activity of RAGs is modulated by Sequence, Length and Phase Position of Flanking Double-stranded DNA
(2015) FEBS J. 282: 4-18.
83. Franklin John, Jinu George, Mrinal Srivastava, Supriya Vartak, P. A. Hassan, V. K. Aswal, Subhas. S. Karki, Sathees C. Raghavan
Structural and Functional Characterization of Pluronic Copolymer Micelle Encapsulated SCR7 as a Potential Anticancer Agent
(2015) Macromolecular Bioscience 15:521-34.
2014
82. Sujeet Kumar, Vidya Gopalakrishnan, Mahesh Hegde, Vivek Rana, Sharad S. Dhepe, Sureshbabu A. Ramareddy, Alberto Leoni, Alessandra Locatelli, Rita Morigi, Mirella Rambaldi, Mrinal Srivastava, Sathees C. Raghavan, Subhas S. Karki
Synthesis and Antiproliferative Activity of Imidazo[2,1-b][1,3,4]thiadiazole Derivatives
(2014) Bioorg. Med. Chem. Let. 24:4682-8.
81. Mrinal Srivastava, Mahesh Hegde, Kishore K. Chiruvella, Jinsha Koroth, Souvari Bhattacharya, Bibha Choudhary, Sathees C. Raghavan
Sapodilla Plum (Achras sapota) Induces Apoptosis in Cancer Cell Lines and Inhibits Tumor Progression in Mice.
(2014) Scientific Report 4:6147.
80. Sujeet Kumar, Mahesh Hegde, Vidya Gopalakrishnan, Renuka VK, Ramareddy SA, De Clercq E, Schols D, Gudibabande Narasimhamurthy AK, Sathees C. Raghavan, Subhas S. Karki
2-(4-Chlorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazoles: Synthesis, cytotoxic activity and mechanism of action
(2014) Eur. J. Med. Chem. 84:687-97. PMID: 25064346.
79. Kothanahally S. Sharathkumar, Ananda Hanumappa, Mahesh Hegde, Kereyagalahally H. Narasimhamurthy, Sathees C. Raghavan, Kanchugarakoppal S. Rangappa
Synthesis and antiproliferative effect of novel 4-thiazolidinone-, pyridine- and piperazine-based conjugates on human leukemic cells
(2014) Eur. J. Med. Chem. 81:341-9. PMID: 2485228.
2013
78. Mridula Nambiar, Mrinal Srivastava, Vidya Gopalakrishnan, Sritha K. Sankaran and Sathees C. Raghavan
G-quadruplex Structures Formed at the HOX11 Breakpoint Region contribute to its fragility during t(10;14) Translocation in T-cell Leukemia
(2013) Mol. Cell. Biol. 33: 4266-81.
77. Chandagirikoppal V. Kavitha, Mridula Nambiar, Pavan B. Narayanaswamy, Elizabeth Thomas, Ujjwal Rathore, Bibha Choudhary, Kanchugarakoppal S. Rangappa, and Sathees C. Raghavan
Propyl-2-(8-(3,4-difluorobenzyl)-2',5'-dioxo-8-azaspiro[bicyclo[3.2.1] octane-3,4'-imidazolidine]-1'-yl)acetate induces apoptosis in human leukemia cells through mitochondrial pathway following cell cycle arrest
(2013) PLoS ONE, 8: e69103.
76. Upasana Sahu, Gopal M. Advirao, Sathees C. Raghavan and Ranjit Giri
8-methoxypyrimido [4’,5’:4,5]thieno(2,3-b) quinoline-4(3H)one, a newer anticancer drug induces neuro 2a neuroblastoma cell death through p53-dependent, caspase-dependent and -independent apoptotic pathways
(2013) PLoS ONE, 8: e66430.
75. Sheetal Sharma, Kuppusamy Panjamurthy, Mrinal Srivastava, Bibha Choudhary, Shahabuddin M.S., Gopal M. Advirao and Sathees C. Raghavan
A novel DNA intercalator, 8-Methoxy pyrimido[4’,5’:4,5]thieno (2,3-b)quinoline-4(3H)-one induces apoptosis in cancer cells, inhibits the tumor progression and enhances lifespan of mice
(2013) Mol. Carcinogenesis 52:413-25.
74. Mridula Nambiar and Sathees C. Raghavan
Chromosomal Translocations among the Healthy Human Population: Implications in Oncogenesis
(2013) Cell. Mol. Life Sci. 70:1381-92.
73. Gurupadaswamy HD, Girish V, Kavitha CV, Sathees C. Raghavan, Khanum SA.
Synthesis and evaluation of 2, 5-di (4-aryloylaryloxymethyl)-1, 3, 4-oxadiazoles as anti-cancer agents
(2013), Eur J Med Chem. 63C:536-54.
2012
72. Mrinal Srivastava, Mridula Nambiar, Sheetal Sharma, Subhas S. Karki, G. Goldsmith, Mahesh Hegde, Sujeet Kumar, Monica Pandey, Ram K. Singh, Pritha Ray, Renuka Natarajan, Madhura Kelkar, Abhijit De, Bibha Choudhary and Sathees C. Raghavan
An Inhibitor of Nonhomologous Endjoining Abrogates Double-strand Break Repair and Impedes Cancer Progression
(2012) Cell 151:1474-87.
71. Ranganatha Somasagara, Mahesh Hegde, Kishore K. Chiruvella, Anjaneyalu Musini, Bibha Choudhary and Sathees C. Raghavan
Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice
(2012) PLoS One 7: e47021.
70. Mayilaadumveettil Nishana and Sathees C. Raghavan
Role of RAGs in the generation of antigen receptor diversity and beyond
(2012) Immunology 137:271-81.
69. Mayilaadumveettil Nishana and Sathees C. Raghavan
A V(D)J recombination nonamer can regulate RAG cleavage at non-B DNA structures: implications in genomic instability and cancer
Biochemical J. (Disease) 448:115-125.
68. Mahesh Hegde, Subhas S. Karki, Elizabeth Thomas, Sujeet Kumar, Kuppusamy Panjamurthy, Ranganatha S. R., Kanchugarakoppal S. Rangappa, Bibha Choudhary and Sathees C. Raghavan
Novel levamisole derivative induces extrinsic pathway of apoptosis in cancer cells and inhibits tumor progression in mice
(2012) PLoS One 7: e43632.
67. Vidya Gopalakrishnan and Sathees C. Raghavan
Sequence and Structural Basis for Chromosomal Fragility During Translocations in Cancer
(2012) Future Oncology 8:1121-34.
66. Sheetal Sharma, and Sathees C. Raghavan
Nonhomologous DNA End Joining in cell-free extracts
(2012) J. Nucleic Acids doi: 10.4061/2010/389129.
65. Vijeth K. Katappadi, Mridula Nambiar and Sathees C. Raghavan
Potential G-quadruplex Formation at Breakpoint Regions of Chromosomal Translocations in Cancer may explain their Fragility
(2012) Genomics, 100:72-80.
64. Mridula Nambiar and Sathees C. Raghavan
A novel mechanism of RAG cleavage induces breaks at BCL2 minor breakpoint cluster region during t(14;18) translocation in follicular lymphoma
(2012) J. Biol. Chem., 287:8688-701.
63. Kishore K. Chiruvella, Robin Sebastian, Sheetal Sharma, Anjali A. Karande, Bibha Choudhary and Sathees C. Raghavan
Nonhomologous DNA End-Joining in Cell-free Extracts of Post Implantation Embryos of Mice
(2012) J. Mol. Biol., 417:197-211.
62. Abani Kanta Naik and Sathees C. Raghavan
Differential Reaction Kinetics, Post Cleavage Complex Formation and Nonamer Binding Domain Dependence Dictates the Structure and Sequence Specific Nuclease Activity of RAGs
(2012) J. Mol. Biol. 415:475-88.
61. Vinaya K, Kavitha CV, Prasanna DS, Chandrappa S, Ranganatha SR, Sathees C. Raghavan, Rangappa KS
Synthesis and Antileukemic Activity of Novel 2‐(4‐(2, 4‐dimethoxybenzoyl) phenoxy)‐1‐(4‐(3‐(piperidin‐4‐yl) propyl) piperidin‐1‐yl) ethanone Derivatives
(2012) Chem Biol Drug Des. 79:360-67.
60. Bibha Choudhary, Anjali Karande and Sathees C. Raghavan
Telomere and Telomerase in Stem Cells: Relevance in Ageing and Disease,
(2012) Front. Bioscience, 4:16-30.
2011
59. Madhusudan N. Purohit, Kuppusamy Panjamurthy, Santhini Elango, Karteek Hebbar, Yergeri C. Mayur and Sathees C. Raghavan
In vitro cytotoxicity and cell cycle analysis of two novel bis-1, 2, 4-triazole derivatives: 1,4-bis[5-(5-mercapto-1,3,4-oxadiazol-2-yl-methyl)-thio-4-(p-tolyl)-1,2,4-triazol-3-yl]-butane (MNP-14) and 1,4-bis[5-(carbethoxy-methyl)-thio-4-(p-ethoxy phenyl) -1,2,4-triazol-3-yl]-butane (MNP-16).
(2011) Nucleosides, Nucleotides, Nucleic Acids 30:873-85.
58. S Teimoori, K Panjamurthy, K Vinaya, DS Prasanna, K Batelia, Sathees C Raghavan, KS Rangappa
Synthesis and antiproliferative activity of novel homopiperazine derivatives in leukemia cells
(2011) Chemistry & Biology Interface 1:59-67.
57. Vinaya K., Kavitha C.V., Chandrappa S., Prasanna D.S., Sathees C. Raghavan and Rangappa K.S.
Synthesis and antileukemic activity of novel 4-(3-(piperidine-4-yl) propyl)piperidine derivatives
(2011) Chemical Biology & Drug Design. 78:622-30.
56. Mridula Nambiar and Sathees C. Raghavan
How DNA Breaks During Chromosomal Translocations in Cancer?
(2011) Nucleic Acids Res. 39:5813-25.
55. Shahabuddin M.S., Mridula Nambiar, Gopal M. Advirao and Sathees C. Raghavan Intercalative Pyrimido[4’,5’:4,5]thieno(2,3-b)quinolines Induce Apoptosis in Leukemic Cells: A Comparative Study of Methoxy and Morpholino Substitution
(2011) Inv. New Drugs 29:873-82.
54. Kishore K. Chiruvella and Sathees C. Raghavan
A natural compound, methyl Angolensate, induces mitochondrial pathway of apoptosis in Daudi cells
(2011) Inv. New Drugs 29:583-92.
53. Shahabuddin M.S., Mridula Nambiar, Balaji T. Moorthy, Prakruthi L. Naik, Bibha Choudhary, Gopal M. Advirao and Sathees C. Raghavan
A Novel Structural Derivative of the Natural Alkaloid Ellipticine, MDPSQ, Induces Necrosis in Leukemic Cells
(2011) Inv. New Drugs 29:523-33.
52. Subhas S. Karki, Kuppusamy Panjamurthy, Sujeet Kumar, Mridula Nambiar, Sureshbabu A. Ramareddy, Kishore K. Chiruvella and Sathees C. Raghavan
Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6-(4'-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent anticancer agents
(2011) Eur. J. Med. Chem. 46:2109-2116.
51. S Teimoori, K Panjamurthy, K Vinaya, DS Prasanna, Sathees C. Raghavan, KS Rangappa
Synthesis and Biological Evaluation of Novel Homopiperazine Derivatives as Anticancer Agents
(2011) J. Cancer Therapy 2, 507-514.
50. Mridula Nambiar, Goldsmith, Balaji T. Moorthy, Mamata V. Joshi, Bibha Choudhary, Michael R. Lieber, Ramakrishna V. Hosur and Sathees C. Raghavan
Characterization of G-quadruplex Structure at BCL2 Major Breakpoint Region of t(14;18) translocation in follicular lymphoma
(2011) Nucleic Acids Res. 39:936-48.
49. Sheetal Sharma, Bibha Choudhary, Kavitha C.V. and Sathees C. Raghavan Nonhomologous DNA End Joining is Most Efficient in Lungs among Somatic Tissues, and is Equivalent to Germ Cells
(2011) Cell. Mol. Life. Sci. 68:661-76.
2010
48. D. S. Prasanna, C. V. Kavitha, K. Vinaya, S. R. Ranganatha, Sathees C. Raghavan, K. S. Rangappa
Synthesis and identification of a New Class 2-(arylcarboxamide)-(S)-6-amino-4,5,6,7-tetrahydrobenzothiazole Derivatives as Antileukemic Agents
(2010) Eur. J. Med. Chem. 45: 5331-6.
47. Balaji T. Moorthy, Subban Ravi, Mrinal Srivastava, Kishore K. Chiruvella, H. Hemlal, Omana Joy and Sathees C. Raghavan
Novel Rhodanine Derivatives Induce Growth Inhibition Followed by Apoptosis
(2010) Biorg. Med. Chem. Let. 20:6297-6301.
46. Tadi Satish Kumar, Vijayalakshmi Kari, Bibha Choudhary, Mridula Nambiar, Akila T.S. and Sathees C. Raghavan
Anti-apoptotic Protein, BCL2, Downregulates Nonhomologous DNA End Joining in Cancer Cells
(2010) J. Biol. Chem. 285:32657-32670.
45. Kavitha C.V, Bibha Choudhary, Sathees C. Raghavan and Muniyappa K.
Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells
(2010) Biochem. Biophy. Res. Commun. 399:575-580.
44. DS Prasanna, CV Kavitha, B Raghava, K Vinaya, SR Ranganatha, Sathees C Raghavan, KS Rangappa
Synthesis and identification of a new class of (S)-2, 6-diamino-4, 5, 6, 7-tetrahydrobenzo [d] thiazole derivatives as potent antileukemic agents
(2010) Investigational New Drugs 28:454-465.
43. Kishore K. Chiruvella, Kuppusamy Panjamurthy, Bibha Choudhary, Omana Joy and Sathees C. Raghavan
Methyl Angolensate from Callus of Indian Redwood Induces Cytotoxicity in Human Breast Cancer Cells
(2010) Int. J. Biomedical Sci. 6:182-194.
42. Doddakunche S. Prasanna, Chandagirikoppal V. Kavitha, Kambappa Vinaya, Somasagara R. Ranganatha, Byregowda Raghava, Yelekere C. Sunil Kumar, Sathees C. Raghavan, and Kanchugarakoppal S. Rangappa
Synthesis and Antileukemic Activity of 1-((S)-2-Amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(substituted phenyl)urea Derivatives
(2010) Bull. Chem. Soc. Jpn. 83: 689-697.
41. Subban Ravi, Kishore K. Chiruvella, K. Rajesha, V. Prabhua and Sathees C. Raghavan
5-isopropylidene-3-ethyl rhodanine induce growth inhibition followed by apoptosis in leukemia cells
(2010) Eur. J. Med. Chem, 45:2748-52.
40. Abani Kanta Naik, Michael R. Lieber and Sathees C. Raghavan
Cytosines, but not purines, determine RAG induced breaks on heteroduplex DNA Structures: Implications for genomic instability
(2010) J. Biol. Chem. 285: 7587-97.
39. Avula Balakrishna, Kishore K. Chiruvella, Mudumala V.N. Reddy, Rajesh Reddy, Sandip Kumar Nayak, Sathees C. Raghavan and Cirandur Suresh Reddy
Synthesis, Characterization and Evaluation of Cytotoxicity of New AminophosphonicAcid Diesters in Human Leukemia Cells
(2010) Lett. Drug Des. Discovery 7: 250-259.
38. Mridula Nambiar and Sathees C. Raghavan
Prevalence of t(14;18) chromosomal translocation in healthy individuals in Indian population
(2010) Ann. Haematology 89:35-43.
37. D Asha, CV Kavitha, S Chandrappa, DS Prasanna, K Vinaya, Sathees C. Raghavan, KS, Rangappa
Novel Ethyl 2-(1-aminocyclobutyl)-5-(benzoyloxy)-6-hydroxy-pyrimidine-4-carboxylate Derivatives: Synthesis and Anticancer Activities
(2010) J. Cancer Therapy 1, 21-28.
36. Shahabuddin M.S., Mridula Nambiar, Bibha Choudhary, Gopal M and Sathees C. Raghavan
A novel DNA intercalator, butylamino-pyrimido [4′, 5′: 4, 5] selenolo (2, 3-b) quinoline, induces cell cycle arrest and apoptosis in leukemic cells
(2010) Inv. New Drugs, 28:35-48.
2009
35. Ranganatha SR, Kavitha CV, Vinaya K, Prasanna DS, Chandrappa S, Sathees C. Raghavan, Rangappa KS
Synthesis and cytotoxic evaluation of novel 2-(4-(2,2,2-trifluoroethoxy)-3-methylpyridin-2-ylthio)-1H-benzo[d]imidazole derivatives
(2009) Arch Pharm Res. 32:1335-43.
34. Thimme Gowda N. R., Kavitha C.V., Omana Joy, Kanchugarakoppal S. Rangappa* and Sathees C. Raghavan*
Synthesis and biological evaluation of novel 1-(4-methoxyphenethyl)-1H-benzimidazole-5-carboxylic acid derivatives and their precursors as antileukemic agents
(2009) Bioorg. Med. Chem. Lett. 19:4594-600.
33. Chandrappa S. , Kavitha C.V., Shahabuddin M.S. Vinaya K. Ananda Kumar C.S, Ranganatha S. R., Sathees C. Raghavan and K. S. Rangappa
Synthesis of 2-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid derivatives and evaluation of their cytotoxicity and induction of apoptosis in human leukemia cells
(2009) Bioorg. Med. Chem. 17:2576-84.
32. Ananda Kumar CS, Kavitha CV, Vinaya K, Benaka Prasad SB., Thimmegowda NR., Chandrappa S, Sathees C. Raghavan, and Rangappa K.S
Synthesis and in vitro cytotoxic evaluation of novel diazaspiro bicyclo hydantoin derivatives in human leukemia cells: A SAR study
(2009) Inv. New Drugs 27:327-37.
31. Kavitha C.V, Mridula Nambiar, Ananda Kumar C.S., Bibha Choudhary, Muniyappa K., Kanchugarakoppal S. Rangappa and Sathees C. Raghavan
Novel Derivatives of Spirohydantoin Induce Growth Inhibition Followed by Apoptosis in Leukemia Cells
(2009) Biochem. Pharmacol. 77:348-363.
30. Shahabuddin M.S, Gopal M and Sathees C. Raghavan
Intercalating, cytotoxic and antitumour activity of 8-Chloro and 4-Morpholinopyrimido [4,5:4,5]thieno(2,3-b)quinolines
(2009) J. Photochem. Photobiol. (B) 94:13-9.
2008
29. Albert Tsai, Haihui Lu, Sathees C. Raghavan, M. Muschen, Chih-Lin Hsieh and Michael R. Lieber
Human Chromosomal Translocations at CpG Sites and a Theoretical Basis for their Lineage and Stage Specificity
(2008) Cell 135: 1130-1142.
28. Kishore K. Chiruvella, Vijayalakshmi Kari, Bibha Choudhary, Mridula Nambiar, Rama Gopal Ghanta, and Sathees C. Raghavan
Methyl Angolensate, a Natural Tetranortriterpenoid Induces Intrinsic Apoptotic Pathway in Leukemic Cells
(2008) FEBS Letters 582:4066-4076.
27. Mridula Nambiar, Vijayalakshmi Kari and Sathees C. Raghavan
Chromosomal translocations in cancer
(2008) Biochim. Biophys. Acta, Reviews on Cancer, 1786:139-152.
26. Mridula Nambiar, Bibha Choudhary, Clementina Rao and Sathees C. Raghavan Detection of Bcl-2/JH Chromosomal Translocations in Paraffin-Embedded Tissue of Follicular Lymphoma patients
(2008) Biomed. Materials, 3, 34103-09.
25. Michael R. Lieber, Sathees C Raghavan and Kefei Yu
Mechanistic aspects of the lymphoid chromosomal translocations
(2008) J. Natl. Cancer Inst., 39:8-11.
24. Abani K Naik and Sathees C Raghavan
P1 nuclease cleavage is dependent on length of the mismatches in DNA
(2008) DNA Repair. 7:1384-1391.
2007
23. Kishore K. Chiruvella, Arifullah Mohammed, Gayathri Dampuri, Rama Gopal Ghanta and Sathees C Raghavan
Phytochemical and antimicrobial studies of methyl angolensate and luteolin-7-0-glucoside isolated from callus cultures of Soymida febrifuga
(2007) Int. J. Biomedical Sci. 3:269-278.
22. Kishore K. Chiruvella, Sritha K. Sankaran, Monika Singh, Mridula Nambiar and Sathees C. Raghavan
Mechanism of DNA double-strand break repair
(2007) ICFAI J. Biotechnology, 1: 7-22.
21. Shahabuddin M.S, Gopal M, and Sathees C Raghavan
Intercalating and antitumour activity of 4-Oxopyrimido[4Ι,5Ι:4,5]thieno(2,3-b)quinoline-4(3H)-one
(2007) J. Cancer Mol., 3:139-146.
20. Sathees C Raghavan and Michael R. Lieber
DNA structures and human diseases
(2007) Front. Biosci., 12:4402-08.
19. Sathees C Raghavan, Jiafeng Gu, Patric Swanson and Michael R. Lieber
The structure-specific nicking of small heteroduplexes by the RAG complex: implications for lymphoid chromosomal translocations
(2007) DNA Repair, 6 751-59.
Book chapters published
18. Ujjayinee Ray and Sathees C Raghavan
Nonhomologous DNA end joining.
(2022) Encyclopedia of Cell Biology 2nd edition, Elsvier, London.
17. Sheetal Sharma and Sathees C. Raghavan
Nonhomologous DNA end joining. Encyclopedia of Cell Biology.
Volume 1; Editors: Ralph A Bradshaw and Philip D Stahl.
(2016) Molecular Cell Biology, pages 451–455.
16. Mrinal Srivastava and Sathees C. Raghavan
The G-factor: Role of G-quadruplexes in Genomic Instability and Cancer,
Editor, David Monchaud, Recent Biological relevance and therapeutic applications of DNA and RNA quadruplexes,
(2014) Published by Future Science, Future Science Ltd, Unitec House, 2 Albert Place, London, N3 1QB, UK.
15. Divyaanka Iyer and Sathees C. Raghavan
“Targeted Cancer Therapy: The Role of BCL2 Inhibitors”
Editor J. N. Govil. In “Recent Developments in Biotechnology
Vol. 7: Drug Discovery, (1st Edition)
(2013) Published by Studium Press LLC, P.O. Box 722 200, Houston, TX 77072-USA.
14. Mridula Nambiar and Sathees C. Raghavan
“Mechanism of Chromosomal fragility in Follicular Lymphoma”
Editor Dr. Manoharan S. In “Diabetes Mellitus and Cancer”
(2009) Published by Excel India Publishers, New Delhi; p 81-86.
Postdoctoral and Ph.D. Publications
13. Michael R. Lieber, Kefei Yu and Sathees C Raghavan
Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocations
(2006) DNA Repair, 5 1234-45.
12. Sathees C Raghavan, Albert Tsai, Chih-Lin Hsieh and Michael R. Lieber Analysis of non-B DNA structure at chromosomal sites in the mammalian genome (2006) Meth. Enzym., 409 301-316.
11. Sathees C Raghavan and Michael R Lieber
DNA structure in human chromosomal translocation sites
(2006) BioEssays, 28 480-494.
10. Sathees C Raghavan, Jiangen Tong and Michael R Lieber
Hybrid joint formation during V(D)J recombination Nonhomologouslogous end joining (2006) DNA Repair, 4 278-285.
9. Sathees C Raghavan, Chih-Lin Hsieh and Michael R. Lieber
V(D)J coding ends but not signal ends can recombine at the bcl-2 major breakpoint region and the rejoining is ligase IV-dependent
(2005) Mol. Cell. Biol., 25 6475-6484.
8. Sathees C Raghavan, Paul Chastain, Jeremy Lee, Sabrina Houston, Balachandra G Hegde, Ralf Langen, Chih-Lin Hsieh, Ian Haworth and Michael R Lieber Evidence for triplex DNA formation at the bcl-2 major breakpoint region
(2005) J. Biol. Chem., 280 22749-22760.
7. Sathees C Raghavan, Patric Swanson, Yunmei Ma and Michael R Lieber
RAGs complex induces DNA double-strand breaks at the bcl-2 major breakpoint region and other non-B DNA structures
(2005) Mol. Cell. Biol., 25 5904-5919.
6. Sathees C Raghavan, Sabrina Houston, Balachandra G Hegde, Ralf Langen and Michael R Lieber
Stability and strand asymmetry in the non-B DNA structure at the bcl-2 major breakpoint region
(2004) J. Biol. Chem., 279 46213-46225.
5. Sathees C Raghavan and Michael R Lieber
Chromosomal translocations and Non-B DNA structures in the human genome
(2004) Cell Cycle, 3 762-768.
4. Sathees C Raghavan, Patrick C Swanson, Xiantuo Wu, Chih-Lin Hsieh and Michael R Lieber
A non-B DNA structure in the bcl-2 major break region is cleaved by RAGs
(2004) Nature 428 88-93.
3. Sathees C Raghavan and Mercy J Raman
Nonhomologous end joining of Complementary and Noncomplementary DNA termini in mouse testicular extracts
(2004) DNA Repair 3 1297-1310.
2. Sathees C Raghavan, Ilan R Kirsch and Michael R Lieber
Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints
(2001) J. Biol. Chem. 276 29126-29133.
1. Sathees C. Raghavan (Chukkurumbal R Sathees) and Mercy J Raman
Mouse testicular extracts process DNA double-strand breaks efficiently by DNA end-to-end joining
(1999) Mutat. Res. DNA Repair 433 1-13.
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